CREATES Research Portfolio
Explore current and completed studies, the people and institutions behind them, reported progress, study locations, sponsors, registries and resulting publications.
4
Published profiles
1
Active or follow-up
3
Completed studies
Study portfolio
4 studies
Controlled human infection study
A landmark controlled human malaria infection study that established the feasibility of safely conducting modern malaria challenge research in malaria-endemic Kenyan adults.
Lead: Dr. Bernhards Ogutu
Nairobi, Kenya
Completed; findings published in peer-reviewed journals.
Preclinical product-development programme
A translational research programme investigating solid lipid nanoparticle formulations intended to improve the delivery and performance of established antimalarial compounds.
Lead: Prof. Florence Oloo, Dr. Bernhards Ogutu
Nairobi, Kenya · Pretoria, South Africa
Completed formulation phases with peer-reviewed preclinical outputs.
Phase IV vaccine safety and effectiveness study
A multicountry Phase IV programme evaluating the safety and real-world effectiveness of the RTS,S/AS01E malaria vaccine following introduction in Ghana, Kenya and Malawi.
Lead: Dr. Bernhards Ogutu
Ghana · Kenya · Malawi
Safety and interim effectiveness findings published; follow-up and evidence translation continue.
Observational paediatric clinical study
A Kenyan paediatric study examining patterns and determinants of lung-function impairment among children and adolescents living with sickle cell disease.
Lead: Dr. Godfrey A. Otieno, Dr. Bernhards Ogutu
Lake Victoria basin, Kenya
Completed; results published in Frontiers in Pediatrics.